NOV-002 Posters and Publications

Biomedicine & Pharmacotherapy, V 64, pp. 73-76 - January, 2010 - Peer Reviewed Publication
Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity.

AACR-EORTC Poster Presentation - Montero - UMiami - November 2009
NOV-002, a Cellular Redox Modulator, Enhances the Anti-Tumor Effect of Adoptively Transferred T cells in a Murine Melanoma Model

AACR-EORTC Poster Presentation - Bowers - MUSC - November 2009
NOV-002 Suppresses Tumor Cell Growth by Modulating Redox-Sensitive Cell Signaling

AACR Poster Presentation - Gumireddy - Wistar - April 2009
Inhibition of tumor cell invasion and ErbB2/PI3K signaling pathways by the glutathione disulfide-mimetic NOV-002

AACR Poster Presentation - Townsend - MUSC - April 2009
In vivo pharmacokinetic and pharmacodynamic behavior of NOV-002, a redox-modulating glutathione disulfide mimetic

AACR Poster Presentation - Townsend - MUSC - April 2009
Polymorphisms of GST pi: Redox regulation through protein S-glutathionylation

AACR Poster Presentation - Manevich - MUSC - April 2009
NOV-002, a redox-modulating glutathione disulfide mimetic, leads to redox-mediated calcium influx and nitric oxide generation through eNOS activation in myeloid cells

Journal of Biological Chemistry V284, pp. 436-445 - January, 2009 - Peer Reviewed Publication
Novel role for glutathione S-transferase p: Regulator of protein S-glutathionylation following oxidative and nitrosative stress

San Antonio Breast Cancer Symposium Poster Presentation - December 2008
Daily injections of the glutathione disulfide mimetic NOV-002 ameliorates hematologic toxicities from neoadjuvant chemotherapy in breast cancer patients enrolled in the NEO-NOVO trial, and significantly increases circulating dendritic cells

AACR Poster Presentation - Diaz-Montero - UMiami - December 2008
Downregulation of T cell activity by cyclophosphamide-induced myeloid derived suppressor cells is reversed by the glutathione disulfide-mimetic NOV-002

AACR Poster Presentation - Poznansky - MGH - December 2008
Positive immunomodulatory effects of NOV-002, an oxidized glutathione mimetic, in a murine model of ovarian cancer

Biomedicine & Pharmacotherapy - Oct 15, 2008 ePub (ahead of print) – Peer Reviewed Publication
Pharmacology of a mimetic of glutathione disulfide, NOV-002

Expert Opinion 17(7): 1075-1083 - June 2008 - Peer Reviewed Publication
NOV-002, a mimetic of glutathione disulfide

ASCO Poster - May 2008
NOV-002 Plus Carboplatin Yields Disease Stability in Platinum-Resistant Ovarian Cancer

Cancer Research 68: (8) - April 15, 2008 - Peer Reviewed Publication
NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance

AACR Poster Presentation - April 2008
NOV-002, a glutathione disulfide mimetic, is a pleiotropic modulator of cellular redox balance

AACR Poster Presentation – April 2007
NOV-002, a glutathione disulfide mimetic, decreases Cisplatin-induced nephrotoxicity and S-glutathionylates serum proteins in mice

AACR Poster Presentation – April 2007
Drug Mediated Oxidative or Nitrosative Stress Induces the Unfolded Protein Response

ASCO Abstract – 2006
NOV-002, a Chemoprotectant/Immunomodulator, Added to First-Line Carboplatin/Paclitaxel in Advanced Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase 1/2, Open-Label, Controlled Study

EORTC Poster Presentation – November 2005
Mechanism of Action Studies of NOV-002; a Novel Glutathione Disulfide Anti-cancer Drug

Clinical Poster Presentation – September 2005
A Randomized Phase 1/2, Open-Label, Controlled Study of NOV-002 in Non-Small Cell Lung Cancer